Azelastine

CAS 58581-89-8C22H24ClN3OMW 381.9

Azelastine (CAS 58581-89-8) — formula C22H24ClN3O, molecular weight 381.9.

Product Overview

CAS Number	58581-89-8
Molecular Formula	C22H24ClN3O
Molecular Weight	381.9
Melting Point	225
LogP	4.9
Applications	Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 96.1, For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis., Methods of Manufacturing: Preparation: BE 778269, D. Vogelsang et al., US 3813384 (1972, 1974 both to Asta-Werke AG), Formulations, Preparations: Azelastine hydrochloride preparations: (AHFS, 2011), Table: Azelastine hydrochloride preparations: (AHFS, 2011) [Table#7930], Azelastine currently is commercially available in the US as azelastine hydrochloride nasal spray preparation, having a pH of approximately 6.8., Azelastine also is commercially available as azelastine hydrochloride ophthalmic solution. Azelastine hydrochloride ophthalmic solution is a sterile solution of the drug in water for injection, the solution contains benzalkonium chloride as a preservative and also contains edetate disodium, hydroxypropyl methylcellulose, sorbitol, and sodium hydroxide. Azelastine hydrochloride ophthalmic solution has a pH of approximately 5-6.5 and an osmolarity of approximately 271-312 mOsmL, L.

Applications

Documented applications: Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 96.1, For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis., Methods of Manufacturing: Preparation: BE 778269, D. Vogelsang et al., US 3813384 (1972, 1974 both to Asta-Werke AG), Formulations, Preparations: Azelastine hydrochloride preparations: (AHFS, 2011), Table: Azelastine hydrochloride preparations: (AHFS, 2011) [Table#7930], Azelastine currently is commercially available in the US as azelastine hydrochloride nasal spray preparation, having a pH of approximately 6.8., Azelastine also is commercially available as azelastine hydrochloride ophthalmic solution. Azelastine hydrochloride ophthalmic solution is a sterile solution of the drug in water for injection, the solution contains benzalkonium chloride as a preservative and also contains edetate disodium, hydroxypropyl methylcellulose, sorbitol, and sodium hydroxide. Azelastine hydrochloride ophthalmic solution has a pH of approximately 5-6.5 and an osmolarity of approximately 271-312 mOsmL, L..

Technical Profile

What this product is

Azelastine is a chemical compound with CAS registry number 58581-89-8 and molecular formula C22H24ClN3O (molecular weight 381.9).

Identification

CAS number: 58581-89-8

Its molecular formula C22H24ClN3O comprises 22 C, 24 H, 1 Cl, 3 N, 1 O atoms.

Also known as: Azelastine · 氮卓斯汀

Frequently Asked Questions

What is the CAS number of Azelastine?

The CAS registry number of Azelastine is 58581-89-8.

What is the molecular formula and molecular weight of Azelastine?

Molecular formula C22H24ClN3O, molecular weight 381.9.

What other names is Azelastine known by?

It is also registered under: Azelastine, 氮卓斯汀.

What are the documented applications of Azelastine?

Recorded applications: Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 96.1, For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis., Methods of Manufacturing: Preparation: BE 778269, D. Vogelsang et al., US 3813384 (1972, 1974 both to Asta-Werke AG), Formulations, Preparations: Azelastine hydrochloride preparations: (AHFS, 2011), Table: Azelastine hydrochloride preparations: (AHFS, 2011) [Table#7930], Azelastine currently is commercially available in the US as azelastine hydrochloride nasal spray preparation, having a pH of approximately 6.8., Azelastine also is commercially available as azelastine hydrochloride ophthalmic solution. Azelastine hydrochloride ophthalmic solution is a sterile solution of the drug in water for injection, the solution contains benzalkonium chloride as a preservative and also contains edetate disodium, hydroxypropyl methylcellulose, sorbitol, and sodium hydroxide. Azelastine hydrochloride ophthalmic solution has a pH of approximately 5-6.5 and an osmolarity of approximately 271-312 mOsmL, L..

PubChem Public Data

Independent reference data for Azelastine (CAS 58581-89-8), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	58581-89-8
PubChem CID	2267
Molecular formula	C22H24ClN3O
IUPAC name	4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
UNII (FDA)	ZQI909440X

Computed descriptors

Molecular Weight	381.9
XLogP3	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	381.1607901
Monoisotopic Mass	381.1607901
Topological Polar Surface Area	35.9
Heavy Atom Count	27

Physicochemical values on record

Melting Point	225
Solubility	9.20e-03 g/L
LogP	4.9
Dissociation Constants	9.54

Documented uses on record

Synonyms and trade names

azelastine; 58581-89-8; Azelastina; 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one; Azelastinum; 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone; ZQI909440X; NSC-758971; CHEBI:2950; DTXSID6022638; 1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one; A 5610; 4-((4-chlorophenyl)methyl)-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one; Vividrin akut Azelastin; RefChem:54397

GHS hazard classification

Reported hazard statements	H302 (100%), H312 (100%), H315 (100%), H332 (100%), H335 (100%), H351 (50%), H413 (50%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

What the public record says

Azelastine · CAS 58581-89-8 · C22H24ClN3O. UNII ZQI909440X. Melting Point: 225; Solubility: 9.20e-03 g/L; LogP: 4.9.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.