Azelastine

Description

Azelastine · CAS 58581-89-8 · C22H24ClN3O. UNII ZQI909440X. Melting Point: 225; Solubility: 9.20e-03 g/L; LogP: 4.9.

Identification

CAS Registry Number	58581-89-8
PubChem CID	2267
Molecular formula	C22H24ClN3O
IUPAC name	4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
UNII (FDA)	ZQI909440X

Computed Descriptors

Molecular Weight	381.9
XLogP3	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	381.1607901
Monoisotopic Mass	381.1607901
Topological Polar Surface Area	35.9
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	225
Solubility	9.20e-03 g/L
LogP	4.9
Dissociation Constants	9.54

Physical description & handling notes

• Solid
• Oil
• 225 °C (hydrochloride salt)
• Sparingly soluble (hydrochloride salt)
• Soluble in methylene chloride
• 189.37 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (100%), H315 (100%), H332 (100%), H335 (100%), H351 (50%), H413 (50%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis.
• Preparation: BE 778269; D. Vogelsang et al., US 3813384 (1972, 1974 both to Asta-Werke AG)
• Intranasal azelastine is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 5 years and older and for the symptomatic treatment of vasomotor rhinitis in patients 12 years and older. Ophthalmic azelastine solution is indicated for the treatment of itchy eyes associated with allergic conjunctivitis. As a 0.15% nasal spray, azelastine hydrochloride is also indicated for over-the-counter treatment of allergies in patients aged six years and older.
• Breast Feeding; Lactation; Milk, Human; Antihistamines

Synonyms

azelastine; 58581-89-8; Azelastina; 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one; Azelastinum; 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone; ZQI909440X; NSC-758971; CHEBI:2950; DTXSID6022638; 1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one; A 5610; 4-((4-chlorophenyl)methyl)-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one; Vividrin akut Azelastin; RefChem:54397

Frequently Asked Questions

What are the CAS number and molecular formula of Azelastine?

CAS 58581-89-8; molecular formula C22H24ClN3O; molecular weight — g/mol.

What other names is Azelastine known by?

azelastine, 58581-89-8, Azelastina, 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one, Azelastinum, 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone.

Is Azelastine classified as hazardous?

Hazard statements reported: H302, H312, H315, H332, H335.

What are the key physical properties of Azelastine?

Melting Point: 225; Solubility: 9.20e-03 g/L; LogP: 4.9; Dissociation Constants: 9.54.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.