Azathioprine（CAS 446-86-6）：分子式 C9H7N7O2S、分子量 277.27。
| CAS号 | 446-86-6 |
|---|---|
| 分子式 | C9H7N7O2S |
| 分子量 | 277.27 |
| 熔点 | 243.5 |
| LogP | 0.1 |
| 应用领域 | Uses: Used as an immunosuppressant and anticancer drug、[Kanerva、p. 1753]、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、exact) in Germany (2009): 3323、Use (kg) in USA (2002): 715、Consumption (g per capita、approx.) in Germany (2009): 0.0305、exact) in Germany (2009): 0.0406、Consumption (g per capita) in the USA (2002): 0.00253、Excretion rate: 0.17、Calculated removal (%): 22、Azathioprine is used alone or in combination with other immunosuppressive therapy to prevent rejection following organ transplantation、and to treat an array of autoimmune diseases、including rheumatoid arthritis、pemphigus、systemic lupus erythematosus、Behcet's disease and other forms of vasculitis、autoimmune hepatitis、atopic dermatitis、myasthenia gravis、neuromyelitis optica (Devic's disease)、restrictive lung disease、and others. It is also an important therapy and steroid-sparing agent for inflammatory bowel disease (such as Crohn's disease and ulcerative colitis) and for multiple sclerosis. In the United States it is currently approved by the Food and Drug Administration (FDA) for use in kidney transplantation from human donors、and for rheumatoid arthritis. Other uses are off-label. (Wikipedia)、Use Classification: Pharmaceuticals、Methods of Manufacturing: Prepn: G.H. Hitchings、G.B. Elion、US 3056785 (1962 to Burroughs Wellcome).、Formulations、Preparations: Imuran (Azathioprine sodium) |
登记用途：Uses: Used as an immunosuppressant and anticancer drug、[Kanerva、p. 1753]、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、exact) in Germany (2009): 3323、Use (kg) in USA (2002): 715、Consumption (g per capita、approx.) in Germany (2009): 0.0305、exact) in Germany (2009): 0.0406、Consumption (g per capita) in the USA (2002): 0.00253、Excretion rate: 0.17、Calculated removal (%): 22、Azathioprine is used alone or in combination with other immunosuppressive therapy to prevent rejection following organ transplantation、and to treat an array of autoimmune diseases、including rheumatoid arthritis、pemphigus、systemic lupus erythematosus、Behcet's disease and other forms of vasculitis、autoimmune hepatitis、atopic dermatitis、myasthenia gravis、neuromyelitis optica (Devic's disease)、restrictive lung disease、and others. It is also an important therapy and steroid-sparing agent for inflammatory bowel disease (such as Crohn's disease and ulcerative colitis) and for multiple sclerosis. In the United States it is currently approved by the Food and Drug Administration (FDA) for use in kidney transplantation from human donors、and for rheumatoid arthritis. Other uses are off-label. (Wikipedia)、Use Classification: Pharmaceuticals、Methods of Manufacturing: Prepn: G.H. Hitchings、G.B. Elion、US 3056785 (1962 to Burroughs Wellcome).、Formulations、Preparations: Imuran (Azathioprine sodium)。
Azathioprine 是一种化工化合物，登记 CAS 号为 446-86-6，分子式 C9H7N7O2S（分子量 277.27）。
登记 CAS 号：446-86-6
其分子式 C9H7N7O2S 由 9 个碳、7 个氢、7 个氮、2 个氧、1 个硫 组成。
别名/同义词：Azathioprine · azathioprine usp
Azathioprine 的 CAS 登记号为 446-86-6。
分子式 C9H7N7O2S，分子量 277.27。
别名/同义词：Azathioprine、azathioprine usp。
登记用途：Uses: Used as an immunosuppressant and anticancer drug、[Kanerva、p. 1753]、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、exact) in Germany (2009): 3323、Use (kg) in USA (2002): 715、Consumption (g per capita、approx.) in Germany (2009): 0.0305、exact) in Germany (2009): 0.0406、Consumption (g per capita) in the USA (2002): 0.00253、Excretion rate: 0.17、Calculated removal (%): 22、Azathioprine is used alone or in combination with other immunosuppressive therapy to prevent rejection following organ transplantation、and to treat an array of autoimmune diseases、including rheumatoid arthritis、pemphigus、systemic lupus erythematosus、Behcet's disease and other forms of vasculitis、autoimmune hepatitis、atopic dermatitis、myasthenia gravis、neuromyelitis optica (Devic's disease)、restrictive lung disease、and others. It is also an important therapy and steroid-sparing agent for inflammatory bowel disease (such as Crohn's disease and ulcerative colitis) and for multiple sclerosis. In the United States it is currently approved by the Food and Drug Administration (FDA) for use in kidney transplantation from human donors、and for rheumatoid arthritis. Other uses are off-label. (Wikipedia)、Use Classification: Pharmaceuticals、Methods of Manufacturing: Prepn: G.H. Hitchings、G.B. Elion、US 3056785 (1962 to Burroughs Wellcome).、Formulations、Preparations: Imuran (Azathioprine sodium)。
Azathioprine（CAS 446-86-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 446-86-6 |
|---|---|
| PubChem CID | 2265 |
| Molecular formula | C9H7N7O2S |
| IUPAC name | 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine |
| UNII (FDA) | MRK240IY2L |
| Molecular Weight | 277.27 |
|---|---|
| XLogP3 | 0.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 277.03819367 |
| Monoisotopic Mass | 277.03819367 |
| Topological Polar Surface Area | 143 |
| Heavy Atom Count | 19 |
| Melting Point | 243.5 |
|---|---|
| Melting Point | dec 243-244 °C |
| Melting Point | 243.5 °C |
| Solubility | 1.07e+00 g/L |
| LogP | 0.1 |
| LogP | log Kow = 0.10 |
| LogP | 0.7 |
| LogP | 0.89 |
| Dissociation Constants | 7.87 (at 25 °C) |
| Dissociation Constants | pKa = 8.2 |
azathioprine; 446-86-6; Azothioprine; Azanin; Azathioprin; Azatioprin; Azamun; Azasan; Ccucol; Imurek; Muran; NSC-39084; Azathioprinum; Azatioprina; BW 57-322; BW-57-322
| Reported hazard statements | H302 (100%), H315 (88.8%), H319 (88.8%), H335 (87.9%), H340 (62.6%), H350 (100%), H360 (58.9%), H317 |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (88.8%): Causes skin irritation [Warning Skin corrosion/irritation]
Azathioprine · CAS 446-86-6 · C9H7N7O2S. UNII MRK240IY2L. Melting Point: 243.5; Melting Point: dec 243-244 °C; Melting Point: 243.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Azathioprine