Alfuzosin

Description

Alfuzosin · CAS 81403-80-7 · C19H27N5O4. UNII 90347YTW5F. Boiling Point: 688; Melting Point: 240; Solubility: 2.82e-01 g/L.

Identification

CAS Registry Number	81403-80-7
PubChem CID	2092
Molecular formula	C19H27N5O4
IUPAC name	N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
UNII (FDA)	90347YTW5F

Computed Descriptors

Molecular Weight	389.4
XLogP3	1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	389.20630436
Monoisotopic Mass	389.20630436
Topological Polar Surface Area	112
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Boiling Point	688
Melting Point	240
Solubility	2.82e-01 g/L
LogP	1.604
LogP	1.4
LogP	1.93
Dissociation Constants	8.13
Dissociation Constants	pKa = 8.13

Physical description & handling notes

• Solid
• In water, 92 mg/L at 25 °C /Estimated/
• 4.56X10-13 mm Hg at 25 °C /Estimated/
• log Kow = 1.86 /Estimated/
• Henry's Law constant = 9.5X10-20 atm-cu m/mol at 25 °C /Estimated/
• Mol wt: 425.92. Crystals from ethanol + ether, mp 225 °C, also reported earlier as 235 °C (dec). pKa 8.13 /Hydrochloride/

GHS Hazard Classification

Reported hazard statements	H373 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Preparation: P.M.J. Manoury, DE 2904445; idem, US 4315007 (1979, 1982 both to Synthelabo)
• Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Romania
• Alfuzosin is used to treat the signs and symptoms of benign prostatic hyperplasia (BPH).
• Alfuzosin is a nonselective alpha-1 adrenergic antagonist used in the therapy of benign prostatic hypertrophy. Alfuzosin is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.

Synonyms

alfuzosin; 81403-80-7; Alfuzosina; Alfuzosine; Alfuzosinum; NSC-760065; N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboxamide; 90347YTW5F; N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide; DTXSID6048549; CHEBI:51141; alphuzosine; N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide; alfusozine; N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboxamide; N-(3-((4-imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboximidic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Alfuzosin?

CAS 81403-80-7; molecular formula C19H27N5O4; molecular weight — g/mol.

What other names is Alfuzosin known by?

alfuzosin, 81403-80-7, Alfuzosina, Alfuzosine, Alfuzosinum, NSC-760065.

Is Alfuzosin classified as hazardous?

Hazard statements reported: H373.

What are the key physical properties of Alfuzosin?

Boiling Point: 688; Melting Point: 240; Solubility: 2.82e-01 g/L; LogP: 1.604.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.