Alectinib

Independent reference data for Alectinib (CAS 1256580-46-7), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

Alectinib is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It is also indicated as an adjuvant treatment in adult patients following tumor resection of ALK-positive non-small cell lung cancer.Alectinib is a tyrosine kinase receptor inhibitor and antineoplastic agent used in the therapy of selected forms of non-small cell lung cancer. Alectinib is associated with a high rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent acute liver injury.

Synonyms and trade names

Alectinib; 1256580-46-7; CH5424802; CH 5424802; AF-802; RO5424802; CH-5424802; AF802; 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile; AF 802; LIJ4CT1Z3Y; RO-5424802; CHEBI:90936; DTXSID50154840; RG7853; 9-ETHYL-6,6-DIMETHYL-8-[4-(MORPHOLIN-4-YL)PIPERIDIN-1-YL]-11-OXO-5H,6H,11H-BENZO[B]CARBAZOLE-3-CARBONITRILE

Regulatory listings held on file

GHS notification summary	66.7% (2 / 3)

GHS hazard classification

GHS notification summary	66.7% (2 / 3)
Reported hazard statements	H341 (33.3%), H361 (33.3%), H373 (33.3%)

This chemical does not meet GHS hazard criteria for 66.7% (2 of 3) of all reports.

H341 (33.3%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

What the public record says

Alectinib · CAS 1256580-46-7 · C30H34N4O2. UNII LIJ4CT1Z3Y. Dissociation Constants: 7.05.

Source: PubChem / Wikidata; the batch COA governs where values differ.