阿霉素（CAS 23214-92-8）：分子式 C27H29NO11、分子量 543.5。
| CAS号 | 23214-92-8 |
|---|---|
| 分子式 | C27H29NO11 |
| 分子量 | 543.5 |
| 熔点 | 229-231 °C |
| LogP | 1.27 |
| 应用领域 | Uses: Therapeutic Category: Antineoplastic、MEDICATION、Use (kg) in USA (2002): 1、Consumption (g per capita) in the USA (2002): 4.29e-06、Calculated removal (%): 8.9、Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia、acute myeloblastic leukemia、Wilms' tumor、neuroblastoma、soft tissue and bone sarcomas、breast carcinoma、ovarian carcinoma、transitional cell bladder carcinoma、thyroid carcinoma、gastric carcinoma、Hodgkin's disease、malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.、Methods of Manufacturing: Adriamycin is a cytotoxic antibiotic isolated from cultures of Streptomyces peucetius var. caesius、a mutant obtained by treating Streptomyces peucetius with N-nitroso-N-methylurethane.、Doxorubicin hydrochloride、Impurities: (8S、10S)-10[(3-amino-2、3、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1、1-dimethoxyethyl)-6、8、11-trihydroxy-1-methoxy-7、9、10-tetrahydrotetracene-5、12-dione、(8S、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6、Daunorubicin、Doxorubicinone、Formulations、Preparations: ADM、Adriamycin、Adriblastin、Adriblastina、DX |
登记用途：Uses: Therapeutic Category: Antineoplastic、MEDICATION、Use (kg) in USA (2002): 1、Consumption (g per capita) in the USA (2002): 4.29e-06、Calculated removal (%): 8.9、Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia、acute myeloblastic leukemia、Wilms' tumor、neuroblastoma、soft tissue and bone sarcomas、breast carcinoma、ovarian carcinoma、transitional cell bladder carcinoma、thyroid carcinoma、gastric carcinoma、Hodgkin's disease、malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.、Methods of Manufacturing: Adriamycin is a cytotoxic antibiotic isolated from cultures of Streptomyces peucetius var. caesius、a mutant obtained by treating Streptomyces peucetius with N-nitroso-N-methylurethane.、Doxorubicin hydrochloride、Impurities: (8S、10S)-10[(3-amino-2、3、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1、1-dimethoxyethyl)-6、8、11-trihydroxy-1-methoxy-7、9、10-tetrahydrotetracene-5、12-dione、(8S、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6、Daunorubicin、Doxorubicinone、Formulations、Preparations: ADM、Adriamycin、Adriblastin、Adriblastina、DX。
阿霉素 是一种化工化合物，登记 CAS 号为 23214-92-8，分子式 C27H29NO11（分子量 543.5）。
登记 CAS 号：23214-92-8
其分子式 C27H29NO11 由 27 个碳、29 个氢、1 个氮、11 个氧 组成。
别名/同义词：阿霉素 · Adriamycin
阿霉素 的 CAS 登记号为 23214-92-8。
分子式 C27H29NO11，分子量 543.5。
别名/同义词：阿霉素、Adriamycin。
登记用途：Uses: Therapeutic Category: Antineoplastic、MEDICATION、Use (kg) in USA (2002): 1、Consumption (g per capita) in the USA (2002): 4.29e-06、Calculated removal (%): 8.9、Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia、acute myeloblastic leukemia、Wilms' tumor、neuroblastoma、soft tissue and bone sarcomas、breast carcinoma、ovarian carcinoma、transitional cell bladder carcinoma、thyroid carcinoma、gastric carcinoma、Hodgkin's disease、malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.、Methods of Manufacturing: Adriamycin is a cytotoxic antibiotic isolated from cultures of Streptomyces peucetius var. caesius、a mutant obtained by treating Streptomyces peucetius with N-nitroso-N-methylurethane.、Doxorubicin hydrochloride、Impurities: (8S、10S)-10[(3-amino-2、3、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1、1-dimethoxyethyl)-6、8、11-trihydroxy-1-methoxy-7、9、10-tetrahydrotetracene-5、12-dione、(8S、6-trideoxy-alpha-levo-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6、Daunorubicin、Doxorubicinone、Formulations、Preparations: ADM、Adriamycin、Adriblastin、Adriblastina、DX。
阿霉素（CAS 23214-92-8）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 23214-92-8 |
|---|---|
| PubChem CID | 31703 |
| Molecular formula | C27H29NO11 |
| IUPAC name | (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
| UNII (FDA) | 80168379AG |
| Molecular Weight | 543.5 |
|---|---|
| XLogP3 | 1.3 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 5 |
| Exact Mass | 543.17406074 |
| Monoisotopic Mass | 543.17406074 |
| Topological Polar Surface Area | 206 |
| Heavy Atom Count | 39 |
| Melting Point | 229-231 °C |
|---|---|
| Melting Point | 230 °C |
| Melting Point | 204 - 205 °C |
| Solubility | ~10 mg/ml |
| Solubility | 1.18e+00 g/L |
| LogP | 1.27 |
| LogP | log Kow = 1.27 |
| LogP | -0.5 |
| LogP | 0.6 |
doxorubicin; Adriamycin; 23214-92-8; Adriablastin; Doxorubicine; 14-Hydroxydaunomycin; Doxorubicinum; Doxorubicina; 14-Hydroxydaunorubicine; NDC 38242-874; NSC 123127; NSC-123127; NSC-759155; 80168379AG; DTXSID8021480; CHEBI:28748
| Reported hazard statements | H302 (100%), H350 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H350 (100%): May cause cancer [Danger Carcinogenicity]
Adriamycin · CAS 23214-92-8 · C27H29NO11. UNII 80168379AG. Melting Point: 229-231 °C; Melting Point: 230 °C; Melting Point: 204 - 205 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Adriamycin