adipamide

Description

adipamide · CAS 628-94-4 · C6H12N2O2. UNII 40DRU033OW. Melting Point: 428 °F (NTP, 1992); Melting Point: 220 °C.

Identification

CAS Registry Number	628-94-4
PubChem CID	12364
Molecular formula	C6H12N2O2
IUPAC name	hexanediamide
UNII (FDA)	40DRU033OW

Computed Descriptors

Molecular Weight	144.17
XLogP3	-1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	144.089877630
Monoisotopic Mass	144.089877630
Topological Polar Surface Area	86.2
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Melting Point	428 °F (NTP, 1992)
Melting Point	220 °C

Physical description & handling notes

• Adipamide is a colorless powder. (NTP, 1992)
• Colorless solid; [CAMEO] mp = 228 deg C and practically insoluble in cold water; [Ullmann] White solid; [Alfa Aesar MSDS]
• PLATES
• Slightly soluble (NTP, 1992)
• SLIGHTLY SOL IN WATER, ETHER; VERY SOL IN ALC

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (97.7%)

Documented Uses

• A diamide derivative of adipic acid; [Ullmann] Used for organic synthesis and as chemical intermediate; [NTP]
• POLYMETHYLENE CHAINS TERMINALLY SUBSTITUTED WITH VARIOUS COMBINATIONS OF CARBOXYLATE, AMINO, AMIDE, OR SULFOXIDE GROUPS WERE TESTED FOR INDUCING ERYTHROID DIFFERENTIATION IN MURINE ERYTHROLEUKEMIA CELLS. ALL POTENT INDUCING AGENTS POSSESSED BOTH A HYDROPHILIC & HYDROPHOBIC PORTION OF THE MOLECULE, AS WELL AS A PLANER PORTION. THE POLYMETHYLENE CHAIN JOINING FUNCTIONAL GROUPS MUST BE FLEXIBLE & MUST BE 5-6 CARBON ATOMS IN LENGTH TO ACHIEVE MAXIMAL ACTIVITY.
• VARIOUS N-SUBSTITUTED POLYMETHYLENE DIAMIDES WERE TESTED FOR THEIR POTENCY TO INDUCE ERYTHROID DIFFERENTIATION IN MURINE ERYTHROLEUKEMIA CELLS. POLYMETHYLENE DIAMIDES HAD NO EFFECT ON THE INDUCTION OF HEMOGLOBIN SYNTHESIS. THE N-ALKYLATED AMIDE GROUP APPEARS TO BE REQUIRED FOR INDUCTION OF DIFFERENTIATION IN MURINE ERYTHROLEUKEMIA CELLS.

Synonyms

Adipamide; 628-94-4; HEXANEDIAMIDE; Adipic diamide; Adipic acid amide; Adipic acid diamide; 1,4-Butanedicarboxamide; NCI-C02095; 40DRU033OW; DTXSID4020032; NSC-7623; DTXCID7032; RefChem:553047; 211-062-5; CCRIS 5883; HSDB 5510

Frequently Asked Questions

What are the CAS number and molecular formula of adipamide?

CAS 628-94-4; molecular formula C6H12N2O2; molecular weight — g/mol.

What other names is adipamide known by?

Adipamide, 628-94-4, HEXANEDIAMIDE, Adipic diamide, Adipic acid amide, Adipic acid diamide.

Is adipamide classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of adipamide?

Melting Point: 428 °F (NTP, 1992); Melting Point: 220 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.