阿卡拉布替尼

阿卡拉布替尼（CAS 1420477-60-6）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Acalabrutinib is indicated for: - The treatment of adult patients with Mantle Cell Lymphoma (MCL) who have received at least one prior therapy. - The treatment of adult patients with chronic lymphocytic leukemia and small lymphocytic lymphoma. - In combination with [rituximab] and [bendamustine] for the treatment of adult patients with previously untreated mantle cell lymphoma (MCL) who are ineligible for autologous hematopoietic stem cell transplantation (HSCT).Acalabrutinib is an oral inhibitor of Bruton’s tyrosine kinase that is used in the therapy of B cell malignancies including refractory mantle cell lymphoma and chronic lymphocytic leukemia. Acalabrutinib has been associated with mild-to-moderate serum enzyme elevations during therapy but has not been linked to instances of idiosyncratic acute liver injury, although it has been associated with cases of reactivation of hepatitis B which can be severe and even fatal.

同义词与商品名

Acalabrutinib; 1420477-60-6; ACP-196; acalabrutinibum; 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide; I42748ELQW; CHEBI:167707; DTXSID401026209; 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide; 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide; 4-(8-Amino-3-((2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl)imidazo(1,5-a)pyrazin-1-yl)-N-2-pyridinylbenzamide; 4-(8-amino-3-((2S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo(1,5-a)pyrazin-1-yl)-N-(pyridin-2-yl)benzamide; 4-(8-amino-3-((2S)-1-but-2-ynoylpyrrolidin-2-yl)imidazo(1,5-a)pyrazin-1-yl)-N-pyridin-2-ylbenzamide; RefChem:57414; L01XE51; DTXCID401510462

已收录的法规名录

GHS notification summary	33.3% (1 / 3)

GHS 危害分类

GHS notification summary	33.3% (1 / 3)
Reported hazard statements	H373 (66.7%)

This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.

H373 (66.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

公开数据库对它的描述

Acalabrutinib · CAS 1420477-60-6 · C26H23N7O2. UNII I42748ELQW. LogP: 0.49.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。