5-甲酰四氢叶酸（CAS 58-05-9）：分子式 C20H23N7O7、分子量 473.4。
| CAS号 | 58-05-9 |
|---|---|
| 分子式 | C20H23N7O7 |
| 分子量 | 473.4 |
| 熔点 | >260 |
| LogP | -1.2 |
| 应用领域 | Uses: Biochemical research.、MEDICATION、For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists、and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate.、Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid、(2) produced microbially.、Manufactoring: Shive、US 2741608 (1956 to Res. Corp.)、Formulations、Preparations: Tablets、5、10、15、and 25 mg. Powder for oral solution、1 mg、following reconstitution. Ampules、3 mg、ml and 5 mg、ml. Vials、50、100、and 350 mg.、Leucovorin calcium、Oral Tablets、5 mg (of leucovorin)、Wellcovorin (with povidone、scored)、Burroughs Wellcome、10 mg (of leucovorin)、Leucovorin Calcium Tablets (scored)、Lederle、15 mg (of leucovorin)、25 mg (of leucovorin)、Parenteral For Injection、50 mg (of leucovorin)、Leucovorin Calcium for Injection、Cetus、Elkins-Sinn、100 mg (of leucovorin)、Wellcovorin、350 mg (of leucovorin)、Injection、3 mg (of leucovorin) per ml、Leucovorin Calcium Injection (with benzyl alcohol 0.9%)、Lederle.、General Manufacturing Information: A member of the folic acid group of vitamins and a growth factor for the bacterium leuconostoc citroforum. Folinic acid is an important metabolite of folic acid and may be the active form in cellular metabolism.、Intermediate product of the metabolism of folic acid、the active form into which that acid is converted in the body、ascorbic acid being a necessary factor in the conversion process.、Information available in 2005 indicated that Leucovorin (folinic acid) was used in the manufacture of pharmaceutical preparations in the following countries: Belgium (1)、Information available in 2005 indicated that Calcium folinate was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Croatia、Czech Republic、Denmark、Finland、France、Germany、Greece、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Luxembourg、Malaysia、Mexico、Netherlands、New Zealand、Norway、Poland、Portugal、Romania、Russian Federation、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、United States、Yugoslavia (1、2)、For more General Manufacturing Information (Complete) data for LEUCOVORIN (6 total)、please visit the HSDB record page. |
登记用途：Uses: Biochemical research.、MEDICATION、For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists、and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate.、Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid、(2) produced microbially.、Manufactoring: Shive、US 2741608 (1956 to Res. Corp.)、Formulations、Preparations: Tablets、5、10、15、and 25 mg. Powder for oral solution、1 mg、following reconstitution. Ampules、3 mg、ml and 5 mg、ml. Vials、50、100、and 350 mg.、Leucovorin calcium、Oral Tablets、5 mg (of leucovorin)、Wellcovorin (with povidone、scored)、Burroughs Wellcome、10 mg (of leucovorin)、Leucovorin Calcium Tablets (scored)、Lederle、15 mg (of leucovorin)、25 mg (of leucovorin)、Parenteral For Injection、50 mg (of leucovorin)、Leucovorin Calcium for Injection、Cetus、Elkins-Sinn、100 mg (of leucovorin)、Wellcovorin、350 mg (of leucovorin)、Injection、3 mg (of leucovorin) per ml、Leucovorin Calcium Injection (with benzyl alcohol 0.9%)、Lederle.、General Manufacturing Information: A member of the folic acid group of vitamins and a growth factor for the bacterium leuconostoc citroforum. Folinic acid is an important metabolite of folic acid and may be the active form in cellular metabolism.、Intermediate product of the metabolism of folic acid、the active form into which that acid is converted in the body、ascorbic acid being a necessary factor in the conversion process.、Information available in 2005 indicated that Leucovorin (folinic acid) was used in the manufacture of pharmaceutical preparations in the following countries: Belgium (1)、Information available in 2005 indicated that Calcium folinate was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Croatia、Czech Republic、Denmark、Finland、France、Germany、Greece、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Luxembourg、Malaysia、Mexico、Netherlands、New Zealand、Norway、Poland、Portugal、Romania、Russian Federation、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、United States、Yugoslavia (1、2)、For more General Manufacturing Information (Complete) data for LEUCOVORIN (6 total)、please visit the HSDB record page.。
5-甲酰四氢叶酸 是一种化工化合物，登记 CAS 号为 58-05-9，分子式 C20H23N7O7（分子量 473.4）。
登记 CAS 号：58-05-9
其分子式 C20H23N7O7 由 20 个碳、23 个氢、7 个氮、7 个氧 组成。
别名/同义词：5-甲酰四氢叶酸 · 5-formyltetrahydrofolic acid
5-甲酰四氢叶酸 的 CAS 登记号为 58-05-9。
分子式 C20H23N7O7，分子量 473.4。
别名/同义词：5-甲酰四氢叶酸、5-formyltetrahydrofolic acid。
登记用途：Uses: Biochemical research.、MEDICATION、For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists、and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate.、Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid、(2) produced microbially.、Manufactoring: Shive、US 2741608 (1956 to Res. Corp.)、Formulations、Preparations: Tablets、5、10、15、and 25 mg. Powder for oral solution、1 mg、following reconstitution. Ampules、3 mg、ml and 5 mg、ml. Vials、50、100、and 350 mg.、Leucovorin calcium、Oral Tablets、5 mg (of leucovorin)、Wellcovorin (with povidone、scored)、Burroughs Wellcome、10 mg (of leucovorin)、Leucovorin Calcium Tablets (scored)、Lederle、15 mg (of leucovorin)、25 mg (of leucovorin)、Parenteral For Injection、50 mg (of leucovorin)、Leucovorin Calcium for Injection、Cetus、Elkins-Sinn、100 mg (of leucovorin)、Wellcovorin、350 mg (of leucovorin)、Injection、3 mg (of leucovorin) per ml、Leucovorin Calcium Injection (with benzyl alcohol 0.9%)、Lederle.、General Manufacturing Information: A member of the folic acid group of vitamins and a growth factor for the bacterium leuconostoc citroforum. Folinic acid is an important metabolite of folic acid and may be the active form in cellular metabolism.、Intermediate product of the metabolism of folic acid、the active form into which that acid is converted in the body、ascorbic acid being a necessary factor in the conversion process.、Information available in 2005 indicated that Leucovorin (folinic acid) was used in the manufacture of pharmaceutical preparations in the following countries: Belgium (1)、Information available in 2005 indicated that Calcium folinate was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Croatia、Czech Republic、Denmark、Finland、France、Germany、Greece、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Luxembourg、Malaysia、Mexico、Netherlands、New Zealand、Norway、Poland、Portugal、Romania、Russian Federation、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、United States、Yugoslavia (1、2)、For more General Manufacturing Information (Complete) data for LEUCOVORIN (6 total)、please visit the HSDB record page.。
5-甲酰四氢叶酸（CAS 58-05-9）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 58-05-9 |
|---|---|
| PubChem CID | 135403648 |
| Molecular formula | C20H23N7O7 |
| IUPAC name | (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| UNII (FDA) | Q573I9DVLP |
| Molecular Weight | 473.4 |
|---|---|
| XLogP3 | -1.2 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Exact Mass | 473.16589610 |
| Monoisotopic Mass | 473.16589610 |
| Topological Polar Surface Area | 216 |
| Heavy Atom Count | 34 |
| Melting Point | >260 |
|---|---|
| Melting Point | 245 °C (decomp) |
| Collision Cross Section | 201.7 Ų [M-H]- |
| Collision Cross Section | 197.5 Ų [M+H]+ |
folinic acid; leucovorin; 58-05-9; 5-Formyltetrahydrofolic acid; folinate; Folinic acid-SF; 5-formyltetrahydrofolate; Acide folinique; 5-Formyl-5,6,7,8-tetrahydrofolic acid; N5-Formyltetrahydrofolic acid; N5-Formyl-5,6,7,8-tetrahydrofolic acid; Q573I9DVLP; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid; DTXSID0048216; CHEBI:15640; (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
5-formyltetrahydrofolic acid · CAS 58-05-9 · C20H23N7O7. UNII Q573I9DVLP. Melting Point: >260; Melting Point: 245 °C (decomp); Collision Cross Section: 201.7 Ų [M-H]-.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 5-formyltetrahydrofolic acid