5-Fluorouracil (CAS 191115-88-5) — formula C4H3FN2O2, molecular weight 130.08.
| CAS Number | 191115-88-5 |
|---|---|
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| Melting Point | Decomposes at 540-541 °F (EPA, 1998) |
| Boiling Point | 361 °C @760 [mm Hg] |
| LogP | -0.89 |
| Applications | Uses: THERAP CAT: Antineoplastic, Antimetabolite suggested for use as insect sterilant ... fluorouracil., MEDICATION, Use (kg) in Switzerland (2009): >100, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 1555, Consumption (g per capita) in Switzerland (2009): 0.013, Consumption (g per capita, approx.) in Germany (2009): 0.012, exact) in Germany (2009): 0.019, Excretion rate: 0.149, Calculated removal (%): 75.1, For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid., Methods of Manufacturing: The direct action of fluorine on uracil yields the cancer chemotherapy agent, 5-fluorouracil., Preparation: ... Heidelberger, Duschinsky, US 2802005 (1957), US 2885396 (1959), Formulations, Preparations: Parenteral Injection, for iv use, 50 mg, mL, Adrucil, Adria, Fluorouracil Injection, Goldline, Lyphomed, Roche, Smith & Nepheq solopak, ml (2.5 g) pharmacy bulk package, mL (5 g) pharmacy bulk package, Smith & Nephew SoloPak., Topical Cream, 1%, Fluoroplex (with benzyl alcohol), Herbert, 5%, Efudex (with parabens and propylene glycol), Roche Derm, Solution, Fluoroplex (with propylene glycol), 2%, Roche Derm., Efudex Solution is available in 10-mL drop dispensers containing either 2% (NDC 0187-3202-10) or 5% (NDC 0187-3203-10) fluorouracil on a weight, weight basis compounded with propylene glycol, tris (hydroxymethyl) aminomethane, hydroxypropyl cellulose, parabens (methyl and propyl) and disodium edetate. Efudex Cream is available in 40-gm tubes containing 5% fluorouracil (NDC 0187-3204-47) in a vanishing cream base consisting of white petrolatum, stearyl alcohol, propylene glycol, polysorbate 60 and parabens (methyl and propyl)., Efudex Solutions, General Manufacturing Information: 2, 4(1H, 3H)-Pyrimidinedione, 5-fluoro-: ACTIVE, Commercial preparations are available in a variety of concentrations and vehicles. Solutions in propylene glycol are more active than cream preparations ... . |
Documented applications: Uses: THERAP CAT: Antineoplastic, Antimetabolite suggested for use as insect sterilant ... fluorouracil., MEDICATION, Use (kg) in Switzerland (2009): >100, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 1555, Consumption (g per capita) in Switzerland (2009): 0.013, Consumption (g per capita, approx.) in Germany (2009): 0.012, exact) in Germany (2009): 0.019, Excretion rate: 0.149, Calculated removal (%): 75.1, For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid., Methods of Manufacturing: The direct action of fluorine on uracil yields the cancer chemotherapy agent, 5-fluorouracil., Preparation: ... Heidelberger, Duschinsky, US 2802005 (1957), US 2885396 (1959), Formulations, Preparations: Parenteral Injection, for iv use, 50 mg, mL, Adrucil, Adria, Fluorouracil Injection, Goldline, Lyphomed, Roche, Smith & Nepheq solopak, ml (2.5 g) pharmacy bulk package, mL (5 g) pharmacy bulk package, Smith & Nephew SoloPak., Topical Cream, 1%, Fluoroplex (with benzyl alcohol), Herbert, 5%, Efudex (with parabens and propylene glycol), Roche Derm, Solution, Fluoroplex (with propylene glycol), 2%, Roche Derm., Efudex Solution is available in 10-mL drop dispensers containing either 2% (NDC 0187-3202-10) or 5% (NDC 0187-3203-10) fluorouracil on a weight, weight basis compounded with propylene glycol, tris (hydroxymethyl) aminomethane, hydroxypropyl cellulose, parabens (methyl and propyl) and disodium edetate. Efudex Cream is available in 40-gm tubes containing 5% fluorouracil (NDC 0187-3204-47) in a vanishing cream base consisting of white petrolatum, stearyl alcohol, propylene glycol, polysorbate 60 and parabens (methyl and propyl)., Efudex Solutions, General Manufacturing Information: 2, 4(1H, 3H)-Pyrimidinedione, 5-fluoro-: ACTIVE, Commercial preparations are available in a variety of concentrations and vehicles. Solutions in propylene glycol are more active than cream preparations ... ..
5-Fluorouracil is a chemical compound with CAS registry number 191115-88-5 and molecular formula C4H3FN2O2 (molecular weight 130.08).
CAS number: 191115-88-5
Its molecular formula C4H3FN2O2 comprises 4 C, 3 H, 1 F, 2 N, 2 O atoms.
Also known as: 5-Fluorouracil · 5-氟尿嘧啶
The CAS registry number of 5-Fluorouracil is 191115-88-5.
Molecular formula C4H3FN2O2, molecular weight 130.08.
It is also registered under: 5-Fluorouracil, 5-氟尿嘧啶.
Recorded applications: Uses: THERAP CAT: Antineoplastic, Antimetabolite suggested for use as insect sterilant ... fluorouracil., MEDICATION, Use (kg) in Switzerland (2009): >100, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 1555, Consumption (g per capita) in Switzerland (2009): 0.013, Consumption (g per capita, approx.) in Germany (2009): 0.012, exact) in Germany (2009): 0.019, Excretion rate: 0.149, Calculated removal (%): 75.1, For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid., Methods of Manufacturing: The direct action of fluorine on uracil yields the cancer chemotherapy agent, 5-fluorouracil., Preparation: ... Heidelberger, Duschinsky, US 2802005 (1957), US 2885396 (1959), Formulations, Preparations: Parenteral Injection, for iv use, 50 mg, mL, Adrucil, Adria, Fluorouracil Injection, Goldline, Lyphomed, Roche, Smith & Nepheq solopak, ml (2.5 g) pharmacy bulk package, mL (5 g) pharmacy bulk package, Smith & Nephew SoloPak., Topical Cream, 1%, Fluoroplex (with benzyl alcohol), Herbert, 5%, Efudex (with parabens and propylene glycol), Roche Derm, Solution, Fluoroplex (with propylene glycol), 2%, Roche Derm., Efudex Solution is available in 10-mL drop dispensers containing either 2% (NDC 0187-3202-10) or 5% (NDC 0187-3203-10) fluorouracil on a weight, weight basis compounded with propylene glycol, tris (hydroxymethyl) aminomethane, hydroxypropyl cellulose, parabens (methyl and propyl) and disodium edetate. Efudex Cream is available in 40-gm tubes containing 5% fluorouracil (NDC 0187-3204-47) in a vanishing cream base consisting of white petrolatum, stearyl alcohol, propylene glycol, polysorbate 60 and parabens (methyl and propyl)., Efudex Solutions, General Manufacturing Information: 2, 4(1H, 3H)-Pyrimidinedione, 5-fluoro-: ACTIVE, Commercial preparations are available in a variety of concentrations and vehicles. Solutions in propylene glycol are more active than cream preparations ... ..
Independent reference data for 5-Fluorouracil (CAS 191115-88-5), compiled from public chemistry databases.
| CAS Registry Number | 191115-88-5 |
|---|---|
| PubChem CID | 3385 |
| Molecular formula | C4H3FN2O2 |
| IUPAC name | 5-fluoro-1H-pyrimidine-2,4-dione |
| UNII (FDA) | U3P01618RT |
| Molecular Weight | 130.08 |
|---|---|
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 130.01785550 |
| Monoisotopic Mass | 130.01785550 |
| Topological Polar Surface Area | 58.2 |
| Heavy Atom Count | 9 |
| Boiling Point | 361 °C @760 [mm Hg] |
|---|---|
| Melting Point | Decomposes at 540-541 °F (EPA, 1998) |
| Melting Point | 282-283 |
| Melting Point | 282 °C (decomposes) |
| Melting Point | 280 - 282 °C |
| Solubility | 11100 |
| Solubility | In water, 1.11X10+4 mg/L at 22 °C |
| Solubility | 5.86e+00 g/L |
| Vapor Pressure | 0.00001 [mm Hg] @25 °C |
| LogP | -0.89 |
5-Fluorouracil; fluorouracil; 51-21-8; Efudex; Fluracil; Fluoroblastin; Carzonal; Queroplex; Fluril; Phthoruracil; Arumel; Timazin; Fluracilum; Ulup; 5-Fluoracil; Fluorouracilum
| GHS notification summary | 32.2% (55 / 171) |
|---|
| GHS notification summary | 32.2% (55 / 171) |
|---|---|
| Reported hazard statements | H301 (66.7%), H312 (33.9%), H315 (36.3%), H319 (36.3%), H335 (35.1%), H340 (35.1%), H360 (37.4%), H412 (24.6%) |
This chemical does not meet GHS hazard criteria for 32.2% (55 of 171) of reports.
H301 (66.7%): Toxic if swallowed [Danger Acute toxicity, oral]
5-Fluorouracil · CAS 191115-88-5 · C4H3FN2O2. UNII U3P01618RT. Boiling Point: 361 °C @760 [mm Hg]; Melting Point: Decomposes at 540-541 °F (EPA, 1998); Melting Point: 282-283.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 5-氟尿嘧啶