5-氟胞嘧啶（CAS 2022-85-7）：分子式 C4H4FN3O、分子量 129.09。
| CAS号 | 2022-85-7 |
|---|---|
| 分子式 | C4H4FN3O |
| 分子量 | 129.09 |
| 熔点 | 296 |
| LogP | -1.1 |
| 应用领域 | Uses: Antifungal Agents、Antimetabolites、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 75.1、For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia、endocarditis and urinary system infections) and、or Cryptococcus (meningitis and pulmonary infections).、Use Classification: Pharmaceuticals -> Antimycotics、Methods of Manufacturing: 5-Fluorouracil is reacted with POCl3 to form 2、4-dichloro-5-fluoropyrimidine which is reacted with NH3 to produce 2-chloro-4-amino-5-fluoropyrimidine. Heating the latter in concentrated HCl yields flucytosine.、Preparation: ... R. Duschinsky、C. Heidelberger、United States of America patent 2945038 (1960 to Hoffmann-La Roche) ... .、Formulations、Preparations: Table: Flucytosine Preparations [Table#4409] |
登记用途：Uses: Antifungal Agents、Antimetabolites、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 75.1、For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia、endocarditis and urinary system infections) and、or Cryptococcus (meningitis and pulmonary infections).、Use Classification: Pharmaceuticals -> Antimycotics、Methods of Manufacturing: 5-Fluorouracil is reacted with POCl3 to form 2、4-dichloro-5-fluoropyrimidine which is reacted with NH3 to produce 2-chloro-4-amino-5-fluoropyrimidine. Heating the latter in concentrated HCl yields flucytosine.、Preparation: ... R. Duschinsky、C. Heidelberger、United States of America patent 2945038 (1960 to Hoffmann-La Roche) ... .、Formulations、Preparations: Table: Flucytosine Preparations [Table#4409]。
5-氟胞嘧啶 是一种化工化合物，登记 CAS 号为 2022-85-7，分子式 C4H4FN3O（分子量 129.09）。
登记 CAS 号：2022-85-7
其分子式 C4H4FN3O 由 4 个碳、4 个氢、1 个氟、3 个氮、1 个氧 组成。
别名/同义词：5-氟胞嘧啶 · 5-Fluorocytosine
5-氟胞嘧啶 的 CAS 登记号为 2022-85-7。
分子式 C4H4FN3O，分子量 129.09。
别名/同义词：5-氟胞嘧啶、5-Fluorocytosine。
登记用途：Uses: Antifungal Agents、Antimetabolites、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 75.1、For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia、endocarditis and urinary system infections) and、or Cryptococcus (meningitis and pulmonary infections).、Use Classification: Pharmaceuticals -> Antimycotics、Methods of Manufacturing: 5-Fluorouracil is reacted with POCl3 to form 2、4-dichloro-5-fluoropyrimidine which is reacted with NH3 to produce 2-chloro-4-amino-5-fluoropyrimidine. Heating the latter in concentrated HCl yields flucytosine.、Preparation: ... R. Duschinsky、C. Heidelberger、United States of America patent 2945038 (1960 to Hoffmann-La Roche) ... .、Formulations、Preparations: Table: Flucytosine Preparations [Table#4409]。
5-氟胞嘧啶（CAS 2022-85-7）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 2022-85-7 |
|---|---|
| PubChem CID | 3366 |
| 分子式 | C4H4FN3O |
| IUPAC 名称 | 6-amino-5-fluoro-1H-pyrimidin-2-one |
| UNII（FDA） | D83282DT06 |
| Molecular Weight | 129.09 |
|---|---|
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 129.03383992 |
| Monoisotopic Mass | 129.03383992 |
| Topological Polar Surface Area | 67.5 |
| Heavy Atom Count | 9 |
| Melting Point | 296 |
|---|---|
| Melting Point | 295-297 °C (dec) |
| Melting Point | 296 °C |
| Solubility | 15000 |
| Solubility | In water, 1.5 g/100 mL at 25 °C |
| Solubility | 1.92e+00 g/L |
| LogP | -1.1 |
| Dissociation Constants | 3.26 |
| Dissociation Constants | pKa1 = 3.26; pKa2 = 10.71 |
5-Fluorocytosine; flucytosine; 2022-85-7; Ancobon; Fluorocytosine; Ancotil; Fluocytosine; 5-Fluorocystosine; Flucytosin; 5-Fluorocytosin; Fluorcytosine; Alcobon; Flucytosinum; 4-Amino-5-fluoropyrimidin-2(1H)-one; Ro 2-9915; Flucitosina
| GHS 通报统计 | 5.9% (4 / 68) |
|---|
| GHS 通报统计 | 5.9% (4 / 68) |
|---|---|
| 已通报的危害声明 | H361 (83.8%) |
5-氟胞嘧啶 · CAS 2022-85-7 · C4H4FN3O. UNII D83282DT06. Melting Point: 296; Melting Point: 295-297 °C (dec); Melting Point: 296 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 5-Fluorocytosine