4-甲基咪唑（CAS 822-36-6）：分子式 C4H6N2、分子量 82.10。
| CAS号 | 822-36-6 |
|---|---|
| 分子式 | C4H6N2 |
| 分子量 | 82.10 |
| 熔点 | 56 °C |
| 沸点 | 263 °C |
| LogP | log Kow = 0.23 |
| 应用领域 | Uses: Used to make pharmaceuticals、antiseptic agents、and photo developing solutions、[HSDB] Present in caramel coloring、tobacco smoke、wine、soy sauce、and other foods、Also formed when ammonia is added to livestock feed to increase nutritional value、Used to make pharmaceuticals、photographic and photothermographic chemicals、dyes、pigments、agricultural chemicals、rubber、and inks、Also used in oven cleaners、as a crosslinking agent for epoxy resin hardeners、corrosion inhibitor for cooling water、and in absorbents that remove acid gases from hydrocarbon or synthesis gas、[NTP]、Plastic Composites Manufacturing [Category: Industry]、Has been reported as one of several compounds resulting from interaction of reducing sugars with ammonia、Major pharmaceutical intermediate、Starting material for drug used for ulcer therapy and other drugs、Photo developing solution.、Household Products: Cosmetics product ingredient: 4-Methylimidazole、Product count: 1、Methods of Manufacturing: In the generally applicable Radziszewski reaction、a 1、2-dicarbonyl compound is condensed with an aldehyde and ammonia (R1 = H) in a molar ratio of 1:1:2、respectively. Replacement of a molar equivalent of ammonia with a primary amine (R1 = alkyl or aryl) leads to the corresponding 1-substituted imidazoles. The reaction is usually carried out in water or a water-alcohol mixture at 50 - 100 °C. Work-up may involve the usual processes (e.g.、distillation、extraction、and crystallization). Distillation leads to imidazole with a purity > 99%. The yield is generally 60 - 85 %. ... Compounds used to prepare simple imidazoles by the Radziszewski reaction: Imidazole: 4(5)-methylimidazole、Dicarbonyl compound: methylglyoxal、Aldehyde: formaldehyde、Amine: ammonia.、General Manufacturing Information: 1H-Imidazole、5-methyl-: ACTIVE |
登记用途：Uses: Used to make pharmaceuticals、antiseptic agents、and photo developing solutions、[HSDB] Present in caramel coloring、tobacco smoke、wine、soy sauce、and other foods、Also formed when ammonia is added to livestock feed to increase nutritional value、Used to make pharmaceuticals、photographic and photothermographic chemicals、dyes、pigments、agricultural chemicals、rubber、and inks、Also used in oven cleaners、as a crosslinking agent for epoxy resin hardeners、corrosion inhibitor for cooling water、and in absorbents that remove acid gases from hydrocarbon or synthesis gas、[NTP]、Plastic Composites Manufacturing [Category: Industry]、Has been reported as one of several compounds resulting from interaction of reducing sugars with ammonia、Major pharmaceutical intermediate、Starting material for drug used for ulcer therapy and other drugs、Photo developing solution.、Household Products: Cosmetics product ingredient: 4-Methylimidazole、Product count: 1、Methods of Manufacturing: In the generally applicable Radziszewski reaction、a 1、2-dicarbonyl compound is condensed with an aldehyde and ammonia (R1 = H) in a molar ratio of 1:1:2、respectively. Replacement of a molar equivalent of ammonia with a primary amine (R1 = alkyl or aryl) leads to the corresponding 1-substituted imidazoles. The reaction is usually carried out in water or a water-alcohol mixture at 50 - 100 °C. Work-up may involve the usual processes (e.g.、distillation、extraction、and crystallization). Distillation leads to imidazole with a purity > 99%. The yield is generally 60 - 85 %. ... Compounds used to prepare simple imidazoles by the Radziszewski reaction: Imidazole: 4(5)-methylimidazole、Dicarbonyl compound: methylglyoxal、Aldehyde: formaldehyde、Amine: ammonia.、General Manufacturing Information: 1H-Imidazole、5-methyl-: ACTIVE。
4-甲基咪唑 是一种化工化合物，登记 CAS 号为 822-36-6，分子式 C4H6N2（分子量 82.10）。
登记 CAS 号：822-36-6
其分子式 C4H6N2 由 4 个碳、6 个氢、2 个氮 组成。
别名/同义词：4-甲基咪唑 · 4-Methylimidazole
4-甲基咪唑 的 CAS 登记号为 822-36-6。
分子式 C4H6N2，分子量 82.10。
别名/同义词：4-甲基咪唑、4-Methylimidazole。
登记用途：Uses: Used to make pharmaceuticals、antiseptic agents、and photo developing solutions、[HSDB] Present in caramel coloring、tobacco smoke、wine、soy sauce、and other foods、Also formed when ammonia is added to livestock feed to increase nutritional value、Used to make pharmaceuticals、photographic and photothermographic chemicals、dyes、pigments、agricultural chemicals、rubber、and inks、Also used in oven cleaners、as a crosslinking agent for epoxy resin hardeners、corrosion inhibitor for cooling water、and in absorbents that remove acid gases from hydrocarbon or synthesis gas、[NTP]、Plastic Composites Manufacturing [Category: Industry]、Has been reported as one of several compounds resulting from interaction of reducing sugars with ammonia、Major pharmaceutical intermediate、Starting material for drug used for ulcer therapy and other drugs、Photo developing solution.、Household Products: Cosmetics product ingredient: 4-Methylimidazole、Product count: 1、Methods of Manufacturing: In the generally applicable Radziszewski reaction、a 1、2-dicarbonyl compound is condensed with an aldehyde and ammonia (R1 = H) in a molar ratio of 1:1:2、respectively. Replacement of a molar equivalent of ammonia with a primary amine (R1 = alkyl or aryl) leads to the corresponding 1-substituted imidazoles. The reaction is usually carried out in water or a water-alcohol mixture at 50 - 100 °C. Work-up may involve the usual processes (e.g.、distillation、extraction、and crystallization). Distillation leads to imidazole with a purity > 99%. The yield is generally 60 - 85 %. ... Compounds used to prepare simple imidazoles by the Radziszewski reaction: Imidazole: 4(5)-methylimidazole、Dicarbonyl compound: methylglyoxal、Aldehyde: formaldehyde、Amine: ammonia.、General Manufacturing Information: 1H-Imidazole、5-methyl-: ACTIVE。
4-甲基咪唑（CAS 822-36-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 822-36-6 |
|---|---|
| PubChem CID | 13195 |
| Molecular formula | C4H6N2 |
| IUPAC name | 5-methyl-1H-imidazole |
| UNII (FDA) | Q64GF9FV4I |
| Molecular Weight | 82.10 |
|---|---|
| XLogP3 | 0.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 82.053098200 |
| Monoisotopic Mass | 82.053098200 |
| Topological Polar Surface Area | 28.7 |
| Heavy Atom Count | 6 |
| Boiling Point | 263 °C |
|---|---|
| Boiling Point | 263 °C @760 [mm Hg] |
| Melting Point | 56 °C |
| Flash Point | 157 °C (315 °F) (closed cup) |
| Density | 1.0416 g/cu cm at 14 °C |
| Vapor Pressure | 0.01 [mmHg] |
| LogP | log Kow = 0.23 |
| LogP | 0.23 |
| Autoignition Temperature | 555 °C |
4-Methylimidazole; 822-36-6; 4-Methyl-1H-imidazole; 1H-Imidazole, 4-methyl-; 4(5)-Methylimidazole; 4-Me-i; 5-Methylimidazole; 4(or 5)-Methylimidazole; IMIDAZOLE, 4-METHYL-; 4-MEI; 1H-Imidazole, 5-methyl-; DTXSID9025617; Q64GF9FV4I; CHEBI:40035; NSC-40744; DTXCID805617
| Regulatory & Food Contact | CIR / INCI: Cosmetics ingredient -> Other (Specify) |
|---|---|
| GHS notification summary | 2.4% (7 / 286) |
| GHS notification summary | 2.4% (7 / 286) |
|---|---|
| Reported hazard statements | H350, H302 (86%), H311 (54.9%), H312 (32.5%), H314 (95.5%), H318 (51.4%), H331 (10.8%), H335 (12.9%) |
H350: May cause cancer [Danger Carcinogenicity]
H360Fd: May damage fertility; Suspected of damaging the unborn child [Danger Reproductive toxicity]
4-Methylimidazole · CAS 822-36-6 · C4H6N2. UNII Q64GF9FV4I. Boiling Point: 263 °C; Boiling Point: 263 °C @760 [mm Hg]; Melting Point: 56 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 4-Methylimidazole