4-氯-10,10-二氧代-10$l^{6}-thia-7,9-二氮杂双环[4.4.0]十-1,3,5-三烯-3-磺酰胺

4-氯-10,10-二氧代-10$l^{6}-thia-7,9-二氮杂双环[4.4.0]十-1,3,5-三烯-3-磺酰胺（CAS 8049-49-8）：分子式 C7H8ClN3O4S2、分子量 297.7。

产品概览

应用领域

登记用途：Uses: MEDICATION (VET)、Antihypertensive Agents、Diuretics、Sodium Chloride Symporter Inhibitors、MEDICATION、Use (kg) in Switzerland (2009): >1000、Use (kg、approx.) in Germany (2009): >50000、exact) in Germany (2009): 50914、Use (kg) in USA (2002): 82500、Consumption (g per capita) in Switzerland (2009): 0.13、Consumption (g per capita、approx.) in Germany (2009): 0.61、exact) in Germany (2009): 0.62、Consumption (g per capita) in the USA (2002): 0.29、Excretion rate: 1、Calculated removal (%): 8.8、For the treatment of high blood pressure and management of edema.、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Pharmaceuticals -> Cardiovascular system -> Diuretics -> Low-ceiling diuretics、thiazides -> Thiazides、plain、Methods of Manufacturing: Hydrochlorothiazide is synthesized by either the reaction of para-formaldehyde with 5-chloro-2、4-disulfamoylaniline in nonaqueous media、or the reaction of formaldehyde with 6-chloro-7-sulfamoyl-2H-1、2、4-benzothiadiazine-1、1-dioxide in aqueous alkaline solution.、Chlorothiazide can be reduced electrolytically or with sodium borohydride or catalytically. ... 3-Chloro-4、6-disulfamoylaniline can be cyclized with formaldehyde to give hydrochlorothiazide.、Preparation: ... Jones、Novello、United States of America patent 3025292 (1962 to Merck & Co)、de Stevens、Werner、United States of America patent 3163645 (1964 to Ciba)、Klosa、German patent 1163332 (1964)、J. S. Irons、T. M. Cook、United States of America patent 3164588 (1965 to Merck & Co).、Formulations、Preparations: Table: Hydrochlorothiazide Preparations [Table#4419]、Table: Amiloride Hydrochloride and Hydrochlorothiazide Preparations [Table#4420]、Table: Captopril and Hydrochlorothiazide Preparations [Table#4421]、Table: Enalapril Maleate and Hydrochlorothiazide Preparations [Table#4422]、For more Formulations、Preparations (Complete) data for Hydrochlorothiazide (10 total)、please visit the HSDB record page.、U.S. Production: (1976) PROBABLY GREATER THAN 1.36X10+6 GRAMS、(1978) PROBABLY GREATER THAN 1.82X10+6 GRAMS、U.S. Imports: (1976) 1.93X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1978) 3.65X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: 2H-1、4-Benzothiadiazine-7-sulfonamide、6-chloro-3、4-dihydro-、1、1-dioxide: ACTIVE、Hydrochlorothiazide decomposes upon irradiation with near-UV light (lambda greater than 310 nm) both in methanol and aqueous solutions. In the photolysis the chlorine substituent is removed to be replaced by either--H or--OR from the solvent ROH. Hydrolysis of the thiadiazine ring is superimposed upon the dechlorination. The presence of oxygen inhibits the decomposition. The mechanism of the photolysis is suggested to involve cation radical formation which facilitates the hydrolysis step. 5-Chloro-2、4-disulphonamido-aniline、the normal hydrolysis product from hydrochlorothiazide、is also susceptible to photolytic dechlorination by a similar mechanism.。

技术档案

这个产品是什么

4-氯-10,10-二氧代-10$l^{6}-thia-7,9-二氮杂双环[4.4.0]十-1,3,5-三烯-3-磺酰胺 是一种化工化合物，登记 CAS 号为 8049-49-8，分子式 C7H8ClN3O4S2（分子量 297.7）。

识别信息

登记 CAS 号：8049-49-8

其分子式 C7H8ClN3O4S2 由 7 个碳、8 个氢、1 个氯、3 个氮、4 个氧、2 个硫 组成。

别名/同义词：4-氯-10,10-二氧代-10$l^{6}-thia-7,9-二氮杂双环[4.4.0]十-1,3,5-三烯-3-磺酰胺 · 4-chloro-10,10-dioxo-10$l^{6}-thia-7,9-diazabicyclo[4.4.0]deca-1,3,5-t riene-3-sulfonamide

常见问题

PubChem 公开数据