2,4,6-Collidine (CAS 108-75-8) — formula C8H11N, molecular weight 121.09 g/mol; category pharmaceutical intermediates and APIs.
| CAS Number | 108-75-8 |
|---|---|
| Molecular Formula | C8H11N |
| Molecular Weight | 121.09 g/mol |
| Melting Point | -44.5 °C |
| Boiling Point | 170.4 °C |
| LogP | log Kow = 1.88 |
| Applications | Uses: Used as a chemical intermediate, dehydrohalogenation agent, tissue fixative for electron microscopy, and solvent for the manufacture of anthraquinones, [HSDB], Chemical intermediate, Used as a chemical intermediate and as a dehydrohalogenation agent, TISSUE FIXATIVE FOR ELECTRON MICROSCOPY, SOLVENT FOR MANUFACTURE OF ANTHRAQUINONES (AS MIXTURE), Methods of Manufacturing: Produced commercially from coal tar to some extent, also produced by Hantzsch pyridine synthesis: Hantzsch, Ann 215, 1 (1882), Mosher in Heterocyclic Compd vol 1, RC Elderfield, ed, (John Wiley, NY, 1950) pp 462-472..., Produced...from acetone and ammonia: Mosher in Kirk-Othmer Encyclopedia of Chemical Technology vol II (NY, 1953) p 287, Compare Durkopf, Ber 21, 2713 (1888), from paraldehyde, acetone, ammonium acetate, and ammonia water: German patent 349, 267, FRDL 14, 539..., Produced...from 3, 5-dimethyl-2-cyclohexen-1-one, and ammonia water: Frank, Meikle, J Am Chem Soc 72, 4184 (1950)., Formulations, Preparations: Grades: Technical (97.5% purity), U.S. Production: (1979) PROBABLY GREATER THAN 2.27X10+6 GRAMS, (1981) PROBABLY GREATER THAN 2.27X10+6 GRAMS, U.S. Imports: (1979) 6.09X10+6 GRAMS (MIXT OF COLLIDINES), (1981) 1.70X10+6 GRAMS (MIXT OF COLLIDINES), General Manufacturing Information: Pyridine, 2, 4, 6-trimethyl-: ACTIVE |
| Category | Pharmaceutical Raw Materials |
Documented applications: Uses: Used as a chemical intermediate, dehydrohalogenation agent, tissue fixative for electron microscopy, and solvent for the manufacture of anthraquinones, [HSDB], Chemical intermediate, Used as a chemical intermediate and as a dehydrohalogenation agent, TISSUE FIXATIVE FOR ELECTRON MICROSCOPY, SOLVENT FOR MANUFACTURE OF ANTHRAQUINONES (AS MIXTURE), Methods of Manufacturing: Produced commercially from coal tar to some extent, also produced by Hantzsch pyridine synthesis: Hantzsch, Ann 215, 1 (1882), Mosher in Heterocyclic Compd vol 1, RC Elderfield, ed, (John Wiley, NY, 1950) pp 462-472..., Produced...from acetone and ammonia: Mosher in Kirk-Othmer Encyclopedia of Chemical Technology vol II (NY, 1953) p 287, Compare Durkopf, Ber 21, 2713 (1888), from paraldehyde, acetone, ammonium acetate, and ammonia water: German patent 349, 267, FRDL 14, 539..., Produced...from 3, 5-dimethyl-2-cyclohexen-1-one, and ammonia water: Frank, Meikle, J Am Chem Soc 72, 4184 (1950)., Formulations, Preparations: Grades: Technical (97.5% purity), U.S. Production: (1979) PROBABLY GREATER THAN 2.27X10+6 GRAMS, (1981) PROBABLY GREATER THAN 2.27X10+6 GRAMS, U.S. Imports: (1979) 6.09X10+6 GRAMS (MIXT OF COLLIDINES), (1981) 1.70X10+6 GRAMS (MIXT OF COLLIDINES), General Manufacturing Information: Pyridine, 2, 4, 6-trimethyl-: ACTIVE.
2,4,6-Collidine is a pharmaceutical intermediate or API compound with CAS registry number 108-75-8 and molecular formula C8H11N (molecular weight 121.09 g/mol), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 108-75-8
Its molecular formula C8H11N comprises 8 C, 11 H, 1 N atoms.
Also known as: 2,4,6-Collidine · 2,4,6-三甲基吡啶
Category: pharmaceutical intermediates and APIs
The CAS registry number of 2,4,6-Collidine is 108-75-8.
Molecular formula C8H11N, molecular weight 121.09 g/mol.
It is also registered under: 2,4,6-Collidine, 2,4,6-三甲基吡啶.
Recorded applications: Uses: Used as a chemical intermediate, dehydrohalogenation agent, tissue fixative for electron microscopy, and solvent for the manufacture of anthraquinones, [HSDB], Chemical intermediate, Used as a chemical intermediate and as a dehydrohalogenation agent, TISSUE FIXATIVE FOR ELECTRON MICROSCOPY, SOLVENT FOR MANUFACTURE OF ANTHRAQUINONES (AS MIXTURE), Methods of Manufacturing: Produced commercially from coal tar to some extent, also produced by Hantzsch pyridine synthesis: Hantzsch, Ann 215, 1 (1882), Mosher in Heterocyclic Compd vol 1, RC Elderfield, ed, (John Wiley, NY, 1950) pp 462-472..., Produced...from acetone and ammonia: Mosher in Kirk-Othmer Encyclopedia of Chemical Technology vol II (NY, 1953) p 287, Compare Durkopf, Ber 21, 2713 (1888), from paraldehyde, acetone, ammonium acetate, and ammonia water: German patent 349, 267, FRDL 14, 539..., Produced...from 3, 5-dimethyl-2-cyclohexen-1-one, and ammonia water: Frank, Meikle, J Am Chem Soc 72, 4184 (1950)., Formulations, Preparations: Grades: Technical (97.5% purity), U.S. Production: (1979) PROBABLY GREATER THAN 2.27X10+6 GRAMS, (1981) PROBABLY GREATER THAN 2.27X10+6 GRAMS, U.S. Imports: (1979) 6.09X10+6 GRAMS (MIXT OF COLLIDINES), (1981) 1.70X10+6 GRAMS (MIXT OF COLLIDINES), General Manufacturing Information: Pyridine, 2, 4, 6-trimethyl-: ACTIVE.
Category: Pharmaceutical Raw Materials.
Independent reference data for 2,4,6-Collidine (CAS 108-75-8), compiled from public chemistry databases.
| CAS Registry Number | 108-75-8 |
|---|---|
| PubChem CID | 7953 |
| Molecular formula | C8H11N |
| Molecular weight | 121.09 g/mol |
| IUPAC name | 2,4,6-trimethylpyridine |
| InChIKey | BWZVCCNYKMEVEX-UHFFFAOYSA-N |
| UNII (FDA) | 7IE4BK5J5V |
| ChEBI ID | CHEBI:189131 |
| Molecular Weight | 121.18 |
|---|---|
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 121.089149355 |
| Monoisotopic Mass | 121.089149355 |
| Topological Polar Surface Area | 12.9 |
| Heavy Atom Count | 9 |
| Boiling Point | 170.4 °C |
|---|---|
| Melting Point | -44.5 °C |
| Flash Point | 58 °C |
| Flash Point | 136 °F |
| Density | 0.913 @ 20 °C/20 °C |
| Vapor Pressure | 1.99 [mmHg] |
| Vapor Pressure | 1.99 mm Hg @ 25 °C |
| LogP | log Kow = 1.88 |
| LogP | 2.01 |
| Ionization Efficiency | 3.93 |
2,4,6-Trimethylpyridine; 108-75-8; 2,4,6-COLLIDINE; s-Collidine; gamma-Collidine; Pyridine, 2,4,6-trimethyl-; sym-Collidine; 2,4,6-Kollidin; alpha,gamma,alpha'-Collidine; 7IE4BK5J5V; NSC-460; DTXSID1051561; RefChem:82156; pyridine, 2,4,6-trimethyl; DTXCID5030113; 203-613-3
| Regulatory & Food Contact | EU Flavoring substances FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS Flavoring Agents |
|---|---|
| GHS notification summary | 0.5% (1 / 187) |
| GHS notification summary | 0.5% (1 / 187) |
|---|---|
| Reported hazard statements | H226 (99.5%), H302 (98.9%), H311 (39.6%), H312 (44.9%), H315 (98.9%), H319 (98.9%), H332 (75.4%), H335 (84%) |
This chemical does not meet GHS hazard criteria for 0.5% (1 of 187) of reports.
H226 (99.5%): Flammable liquid and vapor [Warning Flammable liquids]
2,4,6-Collidine is identified by CAS 108-75-8, molecular formula C8H11N and molecular weight 121.09 g/mol. UNII 7IE4BK5J5V; ChEBI 189131; InChIKey BWZVCCNYKMEVEX-UHFFFAOYSA-N. Boiling Point: 170.4 °C; Melting Point: -44.5 °C; Flash Point: 58 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 2,4,6-三甲基吡啶