2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮

2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮（CAS 104206-65-7）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Nitisinone under the brand name ORFADIN is indicated as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1. Under the name HARLIKU, nitisinone is indicated for the reduction of urine homogentisic acid (HGA) in adult patients with alkaptonuria (AKU).Nitisinone is an inhibitor of the tyrosine catabolism that is used to treat hereditary tyrosinemia, type 1, in which accumulation of intermediates of tyrosine metabolism causes severe and progressive hepatic and renal injury. Nitisinone has been associated with mild, transient serum aminotransferase elevations, but has not been linked to instances of clinically apparent acute liver injury or jaundice.

同义词与商品名

Nitisinone; 104206-65-7; Orfadin; 2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; nitisinona; nitisinonum; SC-0735; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; NITYR; 1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethyl)benzoyl)-; K5BN214699; DTXSID9042673; CHEBI:50378; 1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]-

GHS 危害分类

Reported hazard statements	H302 (100%), H311 (96.6%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H311 (96.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]

公开数据库对它的描述

2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione · CAS 104206-65-7 · C14H10F3NO5. UNII K5BN214699. Solubility: 8.11e-03 g/L; LogP: 1.6.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。