1A,25-二羟基胆钙化醇（CAS 32222-06-3）：分子式 C27H44O3、分子量 416.6。
| CAS号 | 32222-06-3 |
|---|---|
| 分子式 | C27H44O3 |
| 分子量 | 416.6 |
| 熔点 | 113-114 |
| LogP | 5.1 |
| 应用领域 | Uses: Active form of vitamin D3 used therapeutically (calcium regulator、vitamin、antihyperparathyroid、antineoplastic、and antipsoriatic)、[Merck Index]、MEDICATION、Bone Density Conservation Agents、Calcium Channel Agonist、Vitamins、Regulates turnover of calcium in the body.、Consumption (g per capita) in the USA (2002): 2.16e-08、Calculated removal (%): 97.6、Used to treat vitamin D deficiency or insufficiency、refractory rickets (vitamin D resistant rickets)、familial hypophosphatemia and hypoparathyroidism、and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.、Formulations、Preparations: Parenteral: Injection、for IV use only: 1 ug、mL Calcijex、(Abbott)、2 ug、(Abbott).、Oral: Capsules: 0.25 ug Rocaltrol (with parabens)、(Roche)、0.5 ug Rocaltrol (with parabens)、(Roche). Solution: 1 ug、mL Calcitriol Oral Solution、(Roxane)、Rocatrol、(Roche).、General Manufacturing Information: 1-alpha-hydroxycholecalciferol、1-OHD3、is synthetic derivative of vitamin D3 that is hydroxylated in 1-alpha position. It is readily hydroxylated in the 25 position by hepatic microsomal system to form 1、25-dihydroxycholecalciferol and was therefore introduced as substitute for this compound. |
登记用途：Uses: Active form of vitamin D3 used therapeutically (calcium regulator、vitamin、antihyperparathyroid、antineoplastic、and antipsoriatic)、[Merck Index]、MEDICATION、Bone Density Conservation Agents、Calcium Channel Agonist、Vitamins、Regulates turnover of calcium in the body.、Consumption (g per capita) in the USA (2002): 2.16e-08、Calculated removal (%): 97.6、Used to treat vitamin D deficiency or insufficiency、refractory rickets (vitamin D resistant rickets)、familial hypophosphatemia and hypoparathyroidism、and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.、Formulations、Preparations: Parenteral: Injection、for IV use only: 1 ug、mL Calcijex、(Abbott)、2 ug、(Abbott).、Oral: Capsules: 0.25 ug Rocaltrol (with parabens)、(Roche)、0.5 ug Rocaltrol (with parabens)、(Roche). Solution: 1 ug、mL Calcitriol Oral Solution、(Roxane)、Rocatrol、(Roche).、General Manufacturing Information: 1-alpha-hydroxycholecalciferol、1-OHD3、is synthetic derivative of vitamin D3 that is hydroxylated in 1-alpha position. It is readily hydroxylated in the 25 position by hepatic microsomal system to form 1、25-dihydroxycholecalciferol and was therefore introduced as substitute for this compound.。
1A,25-二羟基胆钙化醇 是一种化工化合物，登记 CAS 号为 32222-06-3，分子式 C27H44O3（分子量 416.6）。
登记 CAS 号：32222-06-3
其分子式 C27H44O3 由 27 个碳、44 个氢、3 个氧 组成。
别名/同义词：1A,25-二羟基胆钙化醇 · 1A,25-dihydroxycholecalciferol
1A,25-二羟基胆钙化醇 的 CAS 登记号为 32222-06-3。
分子式 C27H44O3，分子量 416.6。
别名/同义词：1A,25-二羟基胆钙化醇、1A,25-dihydroxycholecalciferol。
登记用途：Uses: Active form of vitamin D3 used therapeutically (calcium regulator、vitamin、antihyperparathyroid、antineoplastic、and antipsoriatic)、[Merck Index]、MEDICATION、Bone Density Conservation Agents、Calcium Channel Agonist、Vitamins、Regulates turnover of calcium in the body.、Consumption (g per capita) in the USA (2002): 2.16e-08、Calculated removal (%): 97.6、Used to treat vitamin D deficiency or insufficiency、refractory rickets (vitamin D resistant rickets)、familial hypophosphatemia and hypoparathyroidism、and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.、Formulations、Preparations: Parenteral: Injection、for IV use only: 1 ug、mL Calcijex、(Abbott)、2 ug、(Abbott).、Oral: Capsules: 0.25 ug Rocaltrol (with parabens)、(Roche)、0.5 ug Rocaltrol (with parabens)、(Roche). Solution: 1 ug、mL Calcitriol Oral Solution、(Roxane)、Rocatrol、(Roche).、General Manufacturing Information: 1-alpha-hydroxycholecalciferol、1-OHD3、is synthetic derivative of vitamin D3 that is hydroxylated in 1-alpha position. It is readily hydroxylated in the 25 position by hepatic microsomal system to form 1、25-dihydroxycholecalciferol and was therefore introduced as substitute for this compound.。
1A,25-二羟基胆钙化醇（CAS 32222-06-3）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 32222-06-3 |
|---|---|
| PubChem CID | 5280453 |
| Molecular formula | C27H44O3 |
| IUPAC name | trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| UNII (FDA) | FXC9231JVH |
| Molecular Weight | 416.6 |
|---|---|
| XLogP3 | 5.1 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 416.32904526 |
| Monoisotopic Mass | 416.32904526 |
| Topological Polar Surface Area | 60.7 |
| Heavy Atom Count | 30 |
| Melting Point | 113-114 |
|---|---|
| Melting Point | 111-115 °C |
| Melting Point | 113 °C |
calcitriol; Rocaltrol; 32222-06-3; Calcijex; Topitriol; 1alpha,25-Dihydroxyvitamin D3; Soltriol; Silkis; 1alpha,25-Dihydroxycholecalciferol; Dihydroxyvitamin D3; Vectical; 1,25-DHCC; Calcitriolum; 1,25-DIHYDROXYCHOLECALCIFEROL; 1alpha,25(OH)2D3; Ro 21-5535
| Reported hazard statements | H300 (100%), H310 (96.7%), H330 (49.5%), H361 (98.9%) |
|---|
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H310 (96.7%): Fatal in contact with skin [Danger Acute toxicity, dermal]
1A,25-dihydroxycholecalciferol · CAS 32222-06-3 · C27H44O3. UNII FXC9231JVH. Melting Point: 113-114; Melting Point: 111-115 °C; Melting Point: 113 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 1A,25-dihydroxycholecalciferol