1-甲基-4-苯基-1,2,3,6-四氢吡啶（CAS 28289-54-5）：分子式 C12H15N、分子量 173.25。
| CAS号 | 28289-54-5 |
|---|---|
| 分子式 | C12H15N |
| 分子量 | 173.25 |
| 熔点 | 40-42 °C |
| 沸点 | 85 to 90 °C @ 0.8 mm Hg |
| LogP | 2.7 |
| 应用领域 | Uses: A contaminant produced during the synthesis of MPPP、a synthetic heroin、it causes irreversible parkinsonism in primates and is used in research laboratories、MPTP is converted to the toxic metabolite MPP+ in the brain where it selectively destroys cells in the substantia nigra. [Merck Index #6294]、1-methyl-4-phenyl-1、2、3、6-tetrahydropyridine (MPTP) is a neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. MPTP can be accidentally produced during the illicit manufacture of MPPP、and that is how its Parkinson-inducing effects were first discovered. MPTP is used to recreate and study the Parkinson's disease in experimental animal models.、Methods of Manufacturing: Prepn as hydrochloride by Grignard reaction: A Ziering et al、J Org Chem 12、894 (1947). Alternative prepn: CJ Schmidle、RC Mansfield、J Am Chem Soc 78、425 (1956).、General Manufacturing Information: Identification as impurity in "synthetic heroin". |
登记用途：Uses: A contaminant produced during the synthesis of MPPP、a synthetic heroin、it causes irreversible parkinsonism in primates and is used in research laboratories、MPTP is converted to the toxic metabolite MPP+ in the brain where it selectively destroys cells in the substantia nigra. [Merck Index #6294]、1-methyl-4-phenyl-1、2、3、6-tetrahydropyridine (MPTP) is a neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. MPTP can be accidentally produced during the illicit manufacture of MPPP、and that is how its Parkinson-inducing effects were first discovered. MPTP is used to recreate and study the Parkinson's disease in experimental animal models.、Methods of Manufacturing: Prepn as hydrochloride by Grignard reaction: A Ziering et al、J Org Chem 12、894 (1947). Alternative prepn: CJ Schmidle、RC Mansfield、J Am Chem Soc 78、425 (1956).、General Manufacturing Information: Identification as impurity in "synthetic heroin".。
1-甲基-4-苯基-1,2,3,6-四氢吡啶 是一种化工化合物，登记 CAS 号为 28289-54-5，分子式 C12H15N（分子量 173.25）。
登记 CAS 号：28289-54-5
其分子式 C12H15N 由 12 个碳、15 个氢、1 个氮 组成。
别名/同义词：1-甲基-4-苯基-1,2,3,6-四氢吡啶 · 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-甲基-4-苯基-1,2,3,6-四氢吡啶 的 CAS 登记号为 28289-54-5。
分子式 C12H15N，分子量 173.25。
别名/同义词：1-甲基-4-苯基-1,2,3,6-四氢吡啶、1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine。
登记用途：Uses: A contaminant produced during the synthesis of MPPP、a synthetic heroin、it causes irreversible parkinsonism in primates and is used in research laboratories、MPTP is converted to the toxic metabolite MPP+ in the brain where it selectively destroys cells in the substantia nigra. [Merck Index #6294]、1-methyl-4-phenyl-1、2、3、6-tetrahydropyridine (MPTP) is a neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. MPTP can be accidentally produced during the illicit manufacture of MPPP、and that is how its Parkinson-inducing effects were first discovered. MPTP is used to recreate and study the Parkinson's disease in experimental animal models.、Methods of Manufacturing: Prepn as hydrochloride by Grignard reaction: A Ziering et al、J Org Chem 12、894 (1947). Alternative prepn: CJ Schmidle、RC Mansfield、J Am Chem Soc 78、425 (1956).、General Manufacturing Information: Identification as impurity in "synthetic heroin".。
1-甲基-4-苯基-1,2,3,6-四氢吡啶（CAS 28289-54-5）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 28289-54-5 |
|---|---|
| PubChem CID | 1388 |
| Molecular formula | C12H15N |
| IUPAC name | 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine |
| UNII (FDA) | 9P21XSP91P |
| Molecular Weight | 173.25 |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 1 |
| Exact Mass | 173.120449483 |
| Monoisotopic Mass | 173.120449483 |
| Topological Polar Surface Area | 3.2 |
| Heavy Atom Count | 13 |
| Boiling Point | 85 to 90 °C @ 0.8 mm Hg |
|---|---|
| Melting Point | 40-42 °C |
| Vapor Pressure | 0.00945 [mmHg] |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 28289-54-5; MPTP; PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-; 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine; DTXSID8040933; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 9P21XSP91P; NSC-139654; CHEBI:17963; RefChem:76325; DTXCID6020933; 248-939-7; 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine; 1-METHYL-4-PHENYL-PIPERIDINE-3-EN; CCRIS 2186
| Reported hazard statements | H301 (100%), H370 (97.5%) |
|---|
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
H370 (97.5%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine · CAS 28289-54-5 · C12H15N. UNII 9P21XSP91P. Boiling Point: 85 to 90 °C @ 0.8 mm Hg; Melting Point: 40-42 °C; Vapor Pressure: 0.00945 [mmHg].
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine