1,2,4-Triazole (CAS 288-88-0) — formula C2H3N3, molecular weight 69.07; category pharmaceutical intermediates and APIs.
| CAS Number | 288-88-0 |
|---|---|
| Molecular Formula | C2H3N3 |
| Molecular Weight | 69.07 |
| Melting Point | 120-121 °C |
| Boiling Point | 260 °C (decomposes) |
| LogP | log Kow = -0.58 |
| Applications | Uses: Used in organic synthesis, [IUCLID], Intermediate, Use Classification: Environmental transformation -> Pesticide transformation products (metabolite, successor), Industry Uses: Intermediate, Consumer Uses: Intermediate, Methods of Manufacturing: 1, 2, 4-Triazole is made by reaction between hydrazine and formamide. Distillation., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 7, 000 - <8, 2021: 4, 000 - <5, 2020: 4, 1H-1, 4-Triazole is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7598], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 1H-1, 4-Triazole. Aggregated National Production Volume: 1 to < 10 million lbs., General Manufacturing Information: Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, 4-Triazole: ACTIVE |
| Category | Pharmaceutical Intermediates |
Documented applications: Uses: Used in organic synthesis, [IUCLID], Intermediate, Use Classification: Environmental transformation -> Pesticide transformation products (metabolite, successor), Industry Uses: Intermediate, Consumer Uses: Intermediate, Methods of Manufacturing: 1, 2, 4-Triazole is made by reaction between hydrazine and formamide. Distillation., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 7, 000 - <8, 2021: 4, 000 - <5, 2020: 4, 1H-1, 4-Triazole is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7598], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 1H-1, 4-Triazole. Aggregated National Production Volume: 1 to < 10 million lbs., General Manufacturing Information: Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, 4-Triazole: ACTIVE.
1,2,4-Triazole is a pharmaceutical intermediate or API compound with CAS registry number 288-88-0 and molecular formula C2H3N3 (molecular weight 69.07), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 288-88-0
Its molecular formula C2H3N3 comprises 2 C, 3 H, 3 N atoms.
Also known as: 1,2,4-Triazole · 1,2,4-三唑
Category: pharmaceutical intermediates and APIs
The CAS registry number of 1,2,4-Triazole is 288-88-0.
Molecular formula C2H3N3, molecular weight 69.07.
It is also registered under: 1,2,4-Triazole, 1,2,4-三唑.
Recorded applications: Uses: Used in organic synthesis, [IUCLID], Intermediate, Use Classification: Environmental transformation -> Pesticide transformation products (metabolite, successor), Industry Uses: Intermediate, Consumer Uses: Intermediate, Methods of Manufacturing: 1, 2, 4-Triazole is made by reaction between hydrazine and formamide. Distillation., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 7, 000 - <8, 2021: 4, 000 - <5, 2020: 4, 1H-1, 4-Triazole is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7598], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 1H-1, 4-Triazole. Aggregated National Production Volume: 1 to < 10 million lbs., General Manufacturing Information: Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, 4-Triazole: ACTIVE.
Category: Pharmaceutical Intermediates.
Independent reference data for 1,2,4-Triazole (CAS 288-88-0), compiled from public chemistry databases.
| CAS Registry Number | 288-88-0 |
|---|---|
| PubChem CID | 9257 |
| Molecular formula | C2H3N3 |
| IUPAC name | 1H-1,2,4-triazole |
| UNII (FDA) | 10MS0Y1RDI |
| Molecular Weight | 69.07 |
|---|---|
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 69.032697108 |
| Monoisotopic Mass | 69.032697108 |
| Topological Polar Surface Area | 41.6 |
| Heavy Atom Count | 5 |
| Boiling Point | 260 °C (decomposes) |
|---|---|
| Boiling Point | 260 °C |
| Melting Point | 120-121 °C |
| Flash Point | 170 °C closed cup |
| Flash Point | 170 °C c.c. |
| Density | 640 kg/m³ |
| Vapor Pressure | 0.6 [mmHg] |
| LogP | log Kow = -0.58 |
| LogP | -0.6 |
| LogP | -0.58 |
1,2,4-TRIAZOLE; 1H-1,2,4-Triazole; 288-88-0; Pyrrodiazole; s-Triazole; DTXSID6027131; 10MS0Y1RDI; NSC-83128; DTXCID207131; CHEBI:35550; RefChem:908322; CHEBI:35560; 206-022-9; 4H-1,2,4-triazole; 63598-71-0; 1,2,4-1H-Triazole
| Reported hazard statements | H302, H319, H361 (42.3%), H412 (10.6%), H360, H402, H313 |
|---|
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
1,2,4-Triazole · CAS 288-88-0 · C2H3N3. UNII 10MS0Y1RDI. Boiling Point: 260 °C (decomposes); Boiling Point: 260 °C; Melting Point: 120-121 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 1,2,4-三唑